From hypothesis to publication — autonomously

H₁ computationally confirmed: Flory-Huggins phase diagram predicts C* ≈ 3.5 µM for Q46 — physiologically accessible in HD striatal neurons — and TF partition coefficients explain the −44.7% target gene expression deficit across two independent genome-wide datasets. H₂ (BET bromodomain inhibitors dissolve mHTT condensates, restoring TF availability) awaits wet-lab validation. Multi-phase EVP ready. Patent AU2026905785.

The hypothesis was that strongly connected components in the collateral sensitivity graph define closed evolutionary traps. Tested against 104,337 susceptibility records from BV-BRC — 18,821 clinical isolates across four WHO critical-priority pathogens. Two of four species yielded a qualifying SCC: K. pneumoniae {imipenem, meropenem, tetracycline} (permutation p = 0.001) and E. coli {colistin, cefotaxime} (OR = 10.13, n = 87). S. aureus yielded none. The carbapenem signal is tetracycline-specific and absent for tigecycline, which distinguishes it from a clonal-lineage artifact, and holds across independent 2009–2014 year bands. This is a retrospective association in surveillance data, not a demonstration of causation; isogenic experimental follow-up is the next step.

Combined QS-inhibitor plus QS-dependent antibiotic therapy creates doubly unfavorable evolutionary landscape for resistant mutants. Lotka-Volterra public-goods model predicts selection coefficient s ≤ −0.05 under combined therapy.

Computationally validates exact O(ε) convergence of performatively stable solutions to classical SP optima across 5 problem families. α = 1.000–1.028, R² ≥ 0.9995. Proportionality constant explicitly characterized: C = L_D·‖x*(0)‖·(1+O(ε)).

SHELVED 4 August 2026 — the central claim does not survive re-testing. The reported 84.9% ergotropy improvement at large cavity detuning was measured with the qubit initialised already excited, so no energy had to be transferred: it is a retention result, not a charging protocol. Re-run with an explicit charging phase (cavity charger → qubit battery), the optimum moves to exact resonance and detuning is strictly harmful — at the claimed optimum of −10g the battery ends with zero ergotropy. The original parameters could not charge at any detuning in any case, since g/κ = 1.0 puts photon transfer (π/2g = 15.7) slower than cavity lifetime (1/κ = 10). The simulation and statistics were sound; the initial state was not.

mHTT Condensates Sequester Transcription Factors in Huntington's Disease

Flory-Huggins phase diagram predicts C* ≈ 3.5 µM for Q46 — physiologically accessible in HD striatal neurons. TF partition coefficients (SP1: 4.2, BRD4: 6.1) explain the observed −44.7% gene expression deficit. BET bromodomain inhibitors (JQ1, OTX015) hypothesised to restore TF availability by disrupting mHTT condensates. Patent AU2026905785.

The Precision Tetrahedron

Loss landscape topology across number formats and multi-target drug discovery. Scaling law (FP32↔BF16 barrier ∝ params⁻⁰·⁴⁷, R²=0.99), placing the basin-separator/regulariser crossover between 38M and 124M parameters. Multi-target Bayesian optimisation across six therapeutic targets including KPC-3 (AMR). Partially retracted in v2: the reported EPTIFIBATIDE dual-target KPC-3/MSH3 convergence does not hold — the MSH3 oracle used the wrong chain of PDB 3THW, making the analyses pseudo-replicates. The precision/LMC findings and the separate KPC-3 result stand.

An Automated Target-Discovery Pipeline Re-Recovers Established Targets in Smoldering MS

A positive-control / methods-validation study. A four-phase pipeline over a 32,239-cell scVI atlas re-recovered Cathepsin S, BET/BRD3 and DNMT1 — targets already established in the literature — from public data in CA-RIM lesions. The point is that the pipeline recovers known biology unprompted, not that these targets are new. An earlier version of this work framed them as novel and used a 36,966-cell atlas that had wrongly pooled in 25 unrelated COVID-19 patients; both are corrected in the current version.

CAPE: Causally-Anchored Physical Encryption from Pulsar Observations

Physical time-capsule encryption anchored to astrophysical causality. 17,255 bits quantum entropy from 30-minute NICER X-ray observation. CAPE-Blind enables Tier 1 deployment using public NANOGrav/PPTA timing archives — no private telescope required. Four Australian provisional patents filed.