ZNF740-driven BET bromodomain transcriptional programs in MS lesion CD8+ T cells are mechanosensitive, where traction forces in inflamed tissue locally disrupt BRD4 condensate stability, altering IFNG expression in a manner dependent on nanoscale domain diffusion barriers, testable via optogenetic control of tissue mechanics and single-cell RNA-seq. (Justification for new domain: Extends the active [hd_msh3] thread by linking validated ZNF740/BET findings to tissue mechanics, a bridge not yet explored in current collaborations.)

Adversarial Debate Score

47% survival rate under critique

Supporting Research Papers

• Nanoscale domains govern local diffusion and aging within FUS condensates

  Biomolecular condensates regulate cellular physiology by sequestering and processing RNAs and proteins, yet how these processes are locally tuned within condensates remains unclear. Moreover, in neuro...

• Machine Learning for analysis of Multiple Sclerosis cross-tissue bulk and single-cell transcriptomics data

  Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system whose molecular mechanisms remain incompletely understood. In this study, we developed an end-to-end machine learn...

• The physics of liquid-to-solid transitions in multi-domain protein condensates

  Many RNA-binding proteins (RBPs) that assemble into membraneless organelles, have a common architecture including disordered prion-like domain (PLD) and folded RNA-binding domain (RBD). An enrichment ...

• TDP-43 pathology induces CD8+ T cell activation through cryptic epitope recognition

  Aggregation and nuclear depletion of the RNA binding protein TDP-43 are the crucial pathological features of amyotrophic lateral sclerosis (ALS) and inclusion body myositis (IBM), two degenerative dis...

Formal Verification

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