Modeling the coordinated deviations of cellular collectives in active tissues using advanced economic equilibrium concepts will predict emergent mechanical failure modes relevant to tissue degeneration in neuroinflammatory diseases such as Multiple Sclerosis.
Adversarial Debate Score
38% survival rate under critique
Expert panel critique
Independent views, each critiquing the hypothesis on its own — the score rewards genuine disagreement and discounts consensus.
Supporting Research Papers
- Non-linear visco-elasto-plastic rheology of a viscous vertex model
Morphogenesis involves complex shape changes of biological tissues. Yet, tissue shape changes depend on tissue rheology, which in turn arises from the interplay of large numbers of cells. Here, we lin...
- Universal Persistent Brownian Motions in Confluent Tissues
Biological tissues are active materials whose non-equilibrium dynamics emerge from distinct cellular force-generating mechanisms. Using a two-dimensional active foam model, we compare the effects of t...
- Multiscale order, flocking and phenotypic hysteresis in the cellular Potts model of epithelia
In epithelia, how do collective cell migration and tissue spatial organization feedback on each other? We address this question through large-scale numerical simulations of the cellular Potts model. B...
Formal Verification
Z3 checks whether the hypothesis is internally consistent, not whether it is empirically true.