Huntington disease phase separation: mHTT low-complexity domain undergoes LLPS forming gel-like condensates that trap transcription factors — condensate-dissolving compounds could restore gene expression programs

Adversarial Debate Score

57% survival rate under critique

Supporting Research Papers

• Molecular Dynamics Simulations Reveal PolyQ-Length-Dependent Conformational Changes in Huntingtin Exon-1: Implications for Environmental Co-Solvent Modulation of Aggregation-Prone States

  Huntington's disease (HD) is caused by CAG-repeat expansion in HTT, which lengthens the polyglutamine (polyQ) tract in huntingtin (HTT) and promotes misfolding and aggregation. While polyQ-length-depe...

• A thermodynamic metric quantitatively predicts disordered protein partitioning and multicomponent phase behavior

  Intrinsically disordered regions (IDRs) of proteins mediate sequence-specific interactions underlying diverse cellular processes, including the formation of biomolecular condensates. Although IDRs str...

• Polymer-Residue Accessibility Shapes Sequence Dependence of Critical Temperatures for Phase Separation

  Biological polymers, such as intrinsically disordered proteins, play a central role in cellular biology, including mediating phase separation and controlling activity of biological condensates. The ph...

• Lemniscate phase trajectories for high-fidelity GHZ state preparation in trapped-ion chains

  In trapped-ion chains, multipartite GHZ states can be prepared natively with the help of a single bichromatic laser pulse. However, higher-order terms in the expansion in the Lamb-Dicke parameter η li...

• Disentangling High Harmonic Generation from Surface and Bulk States of a Topological Insulator

  The discovery of topological phases has introduced a new dimension to materials science. Three-dimensional (3D) topological insulators (TIs) are a remarkable class of matter that is insulating in the ...

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