Incorporating evolutionary trade-off models from antibiotic resistance studies into active foam models of confluent tissues will reveal that cellular force fluctuations can mimic adaptive fitness landscapes, predicting spatial patterns of resistance emergence.
Adversarial Debate Score
55% survival rate under critique
Model Critiques
Supporting Research Papers
- Exploiting evolutionary trade-offs to combat antibiotic resistance
Antibiotic resistance frequently evolves through fitness trade-offs in which the genetic alterations that confer resistance to a drug can also cause growth defects in resistant cells. Here, through ex...
- The Fitness Cost of Antibiotic Resistance: A Critical Factor in Bacterial Adaptation
Antibiotic resistance often incurs fitness costs that can impair bacterial growth, competitiveness, or adaptability in drug-free environments. However, these disadvantages are frequently offset by com...
- Universal Persistent Brownian Motions in Confluent Tissues
Biological tissues are active materials whose non-equilibrium dynamics emerge from distinct cellular force-generating mechanisms. Using a two-dimensional active foam model, we compare the effects of t...
- Pleotropic Effects of Antibiotic Resistance Mutation
Antibiotic resistance mutations (AMRs) alter the phenotypic (physical) characteristics of an organism, which may result in enhanced fitness under antibiotic stress. However, these mutations often infe...
- Identification of Evolutionary Trade‐Offs Associated With High‐Level Colistin Resistance in Acinetobacter baumannii
Colistin (COL) belongs to the polymyxin group of drugs, which possesses a positive charge and interacts with lipopolysaccharide (LPS) of Gram‐negative bacterial outer membranes. Acinetobacter baumanni...
Formal Verification
Z3 checks whether the hypothesis is internally consistent, not whether it is empirically true.